A series of thiosemicarbazide derivatives was designed and synthesized by reaction\nof carboxylic acid hydrazide with isothiocyanates. The molecular structures of the investigated\nthiosemicarbazides were confirmed and characterized by spectroscopic analysis. The conformational\npreference of carbonylthiosemicarbazide chain and intra- and intermolecular interactions in the\ncrystalline state were characterized using X-ray analysis. The antituberculosis activity of the target\ncompounds were tested in vitro against four Mycobacterium strains: M. H37Ra, M. phlei, M. smegmatis,\nM. timereck. The most active compounds were those with 2-pyridine ring. They exhibited lower\nminimal inhibitory concentration (MIC) values in the range................
Loading....